Sophisticated Analytical Instrument Facility

CSIR-Central Drug Research Institute, Lucknow

Supported by: Department of Science & Technology ( Govt. of India)

SAIF Users are request to register on for online sample information submission and make online payment for analysis.

NMR Spectroscopy (NMR)

Over the past 50 years since the first commercial high resolution NMR spectrometers were introduced, nuclear magnetic resonance spectroscopy, commonly referred to as NMR, has become the preeminent technique for determining the structure of organic compounds and various stages of drug development. Of all the spectroscopic methods, it is the only one for which a complete analysis and interpretation of the entire spectrum is normally expected. With the instrumental and methodological advancements that took place in the past few decades, now NMR has become even more beneficial for a wide variety of researchers. Now in addition to liquids NMR can also be carried out on variety of compounds in various forms that includes polymer gels, lipids, tissue samples, swollen resins, plant material, food samples, solids, etc. NMR facility in SAIF, CDRI is highly regarded for its versatility in the types of samples we can work on e.g. organic, biochemical, geological, agricultural and biomedical material) as well as the number of nuclei that can be studied by solution and semi solid NMR. The NMR facility in SAIF, CDRI has a total of three superconducting magnet systems:

Agilent DD2 - 700 MHz NMR, USA
  • Equipped with
    a) 5 mm Z-gradient triple resonance {HCN} VT-inverse probe with 2H decoupling and
    b) 5mm Z-gradient triple resonance VT-cold probe Apart from routine analysis 700 MHz NMR spectrometer is equipped to acquire multidimensional experiments on isotopically labelled (13C/15N/2H) samples
    Capable of performing C-detection experiments
Advance - 400 MHz Bruker, Switzerland
  • 5 mm Broadband Inverse Probe (Z-Grd) with VT unit Additionally equipped with HR-MAS dual 13C/1H (Z-Grd) 4mm probe
Bruker Avlll-300 MHz Bruker, Switzerland
  • 5 mm Broadband Inverse probe with VT unit