SAIF
Sophisticated Analytical Instrument Facility

CSIR-Central Drug Research Institute, Lucknow

Supported by: Department of Science & Technology ( Govt. of India)

Sample submission is open from 1st June 2020.

NMR Spectroscopy (NMR)

Over the past 50 years since the first commercial high resolution NMR spectrometers were introduced, nuclear magnetic resonance spectroscopy, commonly referred to as NMR, has become the preeminent technique for determining the structure of organic compounds and various stages of drug development. Of all the spectroscopic methods, it is the only one for which a complete analysis and interpretation of the entire spectrum is normally expected. With the instrumental and methodological advancements that took place in the past few decades, now NMR has become even more beneficial for a wide variety of researchers. Now in addition to liquids NMR can also be carried out on variety of compounds in various forms that includes polymer gels, lipids, tissue samples, swollen resins, plant material, food samples, solids, etc. NMR facility in SAIF, CDRI is highly regarded for its versatility in the types of samples we can work on e.g. organic, biochemical, geological, agricultural and biomedical material) as well as the number of nuclei that can be studied by solution and semi solid NMR. The NMR facility in SAIF, CDRI has a total of two superconducting magnet systems:

Agilent DD2 - 700 MHz NMR, USA
  • Equipped with 5 mm Z-gradient triple resonance {HCN} VT-inverse probe with 2H decoupling and 5mm Z-gradient triple resonance VT-cold probe
  • Apart from routine analysis 700 MHz nmr is equipped to acquire multidimensional experiments on isotopically labelled (13C/15N/2H) samples
  • Capable of performing C-detection experiments
  • For the efficient usage of the facility users may opt for low-field NMR spectrometers in the facility for their routine usage. It is advisable that the user may bring a low field NMR spectrum on the same sample and concentration.
Advance - 400 MHz Bruker, Switzerland
  • 5mm Broadband Inverse Probe (Z-Grd) with VT unit (-150oC to +180oC)
  • Additionally equipped with HR-MAS dual 13C/1H (Z-Grd) 4mm probe
  • Capable of performing Two-dimensional multinuclear NMR
  • Floppy backup, CD backup, Ethernet compatible networking
  • User friendly menu-driven software
Bruker Avlll-300 MHz Bruker, Switzerland
  • 5mm Broadband Inverse probe with VT unit (-150oC to +180oC)
  • Capability of performing Two-dimensional multinuclear NMR
  • Floppy backup, CD backup, Ethernet compatible networking
  • User friendly menu-driven software